Publications

2023

Shoyer, T Curtis, Evan M. Gates, Jolene I. Cabe, Aarti N. Urs, Daniel E. Conway, and Brenton D. Hoffman. “Coupling during collective cell migration is controlled by a vinculin mechanochemical switch.” Proceedings of the National Academy of Sciences of the United States of America 120, no. 50 (December 2023): e2316456120. https://doi.org/10.1073/pnas.2316456120.

Chirasani, Venkat R., Mohammad Ashhar I. Khan, Juilee N. Malavade, Nikolay V. Dokholyan, Brenton D. Hoffman, and Sharon L. Campbell. “Molecular basis and cellular functions of vinculin-actin directional catch bonding.” Nature Communications 14, no. 1 (December 2023): 8300. https://doi.org/10.1038/s41467-023-43779-x.

Tao, Arnold, Andrew S. LaCroix, T Curtis Shoyer, Vidya Venkatraman, Karen L. Xu, Bradley Feiger, and Brenton D. Hoffman. “Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions.” Developmental Cell 58, no. 6 (March 2023): 522-534.e7. https://doi.org/10.1016/j.devcel.2023.02.015.

2022

Highland, T., S. M. Parker, H. Price, M. Reynolds, S. He, B. D. Hoffman, and A. Wax. “Combined Quantitative Phase Microscopy and Förster Resonance Energy Transfer Imaging for Analyzing Endothelial Cell Shear Stress Response.” In Optics InfoBase Conference Papers, 2022.

Andress, Benjamin D., Rebecca M. Irwin, Ishaan Puranam, Brenton D. Hoffman, and Amy L. McNulty. “A Tale of Two Loads: Modulation of IL-1 Induced Inflammatory Responses of Meniscal Cells in Two Models of Dynamic Physiologic Loading.” Front Bioeng Biotechnol 10 (2022): 837619. https://doi.org/10.3389/fbioe.2022.837619.

2021

Menaesse, Audrey, Daniel Sumetsky, Nicolas Emanuely, Jeremy L. Stein, Evan M. Gates, Brenton D. Hoffman, and Nada N. Boustany. “Simplified Instrument Calibration for Wide-Field Fluorescence Resonance Energy Transfer (FRET) Measured by the Sensitized Emission Method.” Cytometry. Part A : The Journal of the International Society for Analytical Cytology 99, no. 4 (April 2021): 407–16. https://doi.org/10.1002/cyto.a.24194.

Parker, S. M., H. Price, M. Reynolds, S. He, B. D. Hoffman, and A. Wax. “Combined quantitative phase microscopy and förster resonance energy transfer for analyzing cell ion dynamics.” In Optics InfoBase Conference Papers, 2021.

Li, Fenfang, Tae Hyun Park, George Sankin, Christopher Gilchrist, Defei Liao, Chon U. Chan, Zheng Mao, Brenton D. Hoffman, and Pei Zhong. “Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles.” Theranostics 11, no. 12 (January 2021): 6090–6104. https://doi.org/10.7150/thno.56813.

2020

Keeley, Daniel P., Eric Hastie, Ranjay Jayadev, Laura C. Kelley, Qiuyi Chi, Sara G. Payne, Jonathan L. Jeger, Brenton D. Hoffman, and David R. Sherwood. “Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding.” Developmental Cell 54, no. 1 (July 2020): 60-74.e7. https://doi.org/10.1016/j.devcel.2020.05.022.

Dumas, J. P., J. Y. Jiang, E. M. Gates, B. D. Hoffman, M. C. Pierce, and N. N. Boustany. “FRET efficiency measurement with a low-cost frequency domain fluorescence lifetime imaging microscope.” In Optics InfoBase Conference Papers, Vol. Part F177-Microscopy-2020, 2020. https://doi.org/10.1364/MICROSCOPY.2020.MTu4A.7.

2019

Ham, Trevor R., Kasie L. Collins, and Brenton D. Hoffman. “Molecular Tension Sensors: Moving Beyond Force.” Current Opinion in Biomedical Engineering 12 (December 2019): 83–94. https://doi.org/10.1016/j.cobme.2019.10.003.

Dumas, John-Paul, James Y. Jiang, Evan M. Gates, Brenton D. Hoffman, Mark C. Pierce, and Nada N. Boustany. “FRET efficiency measurement in a molecular tension probe with a low-cost frequency-domain fluorescence lifetime imaging microscope.” Journal of Biomedical Optics 24, no. 12 (December 2019): 1–11. https://doi.org/10.1117/1.jbo.24.12.126501.

Mosier, Jenna A., Aniqua Rahman-Zaman, Matthew R. Zanotelli, Jacob A. VanderBurgh, Francois Bordeleau, Brenton D. Hoffman, and Cynthia A. Reinhart-King. “Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains.” Biophysical Journal 117, no. 9 (November 2019): 1692–1701. https://doi.org/10.1016/j.bpj.2019.09.024.

Sengupta, Swarnali, Katheryn E. Rothenberg, Hanjun Li, Brenton D. Hoffman, and Nenad Bursac. “Altering integrin engagement regulates membrane localization of Kir2.1 channels.” Journal of Cell Science 132, no. 17 (September 2019): jcs225383. https://doi.org/10.1242/jcs.225383.

Gilchrist, Christopher L., Holly A. Leddy, Laurel Kaye, Natasha D. Case, Katheryn E. Rothenberg, Dianne Little, Wolfgang Liedtke, Brenton D. Hoffman, and Farshid Guilak. “TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.” Proc Natl Acad Sci U S A 116, no. 6 (February 5, 2019): 1992–97. https://doi.org/10.1073/pnas.1811095116.

Gates, Evan M., Andrew S. LaCroix, Katheryn E. Rothenberg, and Brenton D. Hoffman. “Improving Quality, Reproducibility, and Usability of FRET-Based Tension Sensors.” Cytometry. Part A : The Journal of the International Society for Analytical Cytology 95, no. 2 (February 2019): 201–13. https://doi.org/10.1002/cyto.a.23688.

2018

Rothenberg, Katheryn E., Ishaan Puranam, and Brenton D. Hoffman. “Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques.” Journal of Visualized Experiments : JoVE, no. 141 (November 2018). https://doi.org/10.3791/58619.

LaCroix, Andrew S., Andrew D. Lynch, Matthew E. Berginski, and Brenton D. Hoffman. “Tunable molecular tension sensors reveal extension-based control of vinculin loading.” ELife 7 (July 2018): e33927. https://doi.org/10.7554/elife.33927.

Rothenberg, Katheryn E., David W. Scott, Nicolas Christoforou, and Brenton D. Hoffman. “Vinculin Force-Sensitive Dynamics at Focal Adhesions Enable Effective Directed Cell Migration.” Biophysical Journal 114, no. 7 (April 2018): 1680–94. https://doi.org/10.1016/j.bpj.2018.02.019.

Graham, David M., Tomas Andersen, Lisa Sharek, Gunes Uzer, Katheryn Rothenberg, Brenton D. Hoffman, Janet Rubin, Martial Balland, James E. Bear, and Keith Burridge. “Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction.” The Journal of Cell Biology 217, no. 3 (March 2018): 895–914. https://doi.org/10.1083/jcb.201706097.

Shams, Hengameh, Brenton D. Hoffman, and Mohammad R. K. Mofrad. “The "Stressful" Life of Cell Adhesion Molecules: On the Mechanosensitivity of Integrin Adhesome.” Journal of Biomechanical Engineering 140, no. 2 (February 2018). https://doi.org/10.1115/1.4038812.

2017

Mao, Mao, Liangli Wang, Chun-Chi Chang, Katheryn E. Rothenberg, Jianyong Huang, Yingxiao Wang, Brenton D. Hoffman, Paloma B. Liton, and Fan Yuan. “Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection.” Mol Ther 25, no. 3 (March 1, 2017): 803–15. https://doi.org/10.1016/j.ymthe.2016.12.009.

Pomeroy, Jordan E., Hung X. Nguyen, Brenton D. Hoffman, and Nenad Bursac. “Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells.” Theranostics 7, no. 14 (2017): 3539–58. https://doi.org/10.7150/thno.20593.

Collins, K. L., E. M. Gates, C. L. Gilchrist, and B. D. Hoffman. “Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine.” In Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine, 3–35, 2017. https://doi.org/10.1016/B978-0-12-803394-4.00001-X.

2015

Hoffman, Brenton D., and Alpha S. Yap. “Towards a Dynamic Understanding of Cadherin-Based Mechanobiology.” Trends in Cell Biology 25, no. 12 (December 2015): 803–14. https://doi.org/10.1016/j.tcb.2015.09.008.