Publications

Rothenberg, Katheryn E., David W. Scott, Nicolas Christoforou, and Brenton D. Hoffman. “Vinculin Force-Sensitive Dynamics at Focal Adhesions Enable Effective Directed Cell Migration.” Biophysical Journal 114, no. 7 (April 2018): 1680–94. https://doi.org/10.1016/j.bpj.2018.02.019.

Graham, David M., Tomas Andersen, Lisa Sharek, Gunes Uzer, Katheryn Rothenberg, Brenton D. Hoffman, Janet Rubin, Martial Balland, James E. Bear, and Keith Burridge. “Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction.” The Journal of Cell Biology 217, no. 3 (March 2018): 895–914. https://doi.org/10.1083/jcb.201706097.

Shams, Hengameh, Brenton D. Hoffman, and Mohammad R. K. Mofrad. “The "Stressful" Life of Cell Adhesion Molecules: On the Mechanosensitivity of Integrin Adhesome.” Journal of Biomechanical Engineering 140, no. 2 (February 2018). https://doi.org/10.1115/1.4038812.

Mao, Mao, Liangli Wang, Chun-Chi Chang, Katheryn E. Rothenberg, Jianyong Huang, Yingxiao Wang, Brenton D. Hoffman, Paloma B. Liton, and Fan Yuan. “Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection.” Mol Ther 25, no. 3 (March 1, 2017): 803–15. https://doi.org/10.1016/j.ymthe.2016.12.009.

Collins, K. L., E. M. Gates, C. L. Gilchrist, and B. D. Hoffman. “Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine.” In Bio Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine, 3–35, 2017. https://doi.org/10.1016/B978-0-12-803394-4.00001-X.

Pomeroy, Jordan E., Hung X. Nguyen, Brenton D. Hoffman, and Nenad Bursac. “Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells.” Theranostics 7, no. 14 (2017): 3539–58. https://doi.org/10.7150/thno.20593.

Hoffman, Brenton D., and Alpha S. Yap. “Towards a Dynamic Understanding of Cadherin-Based Mechanobiology.” Trends in Cell Biology 25, no. 12 (December 2015): 803–14. https://doi.org/10.1016/j.tcb.2015.09.008.

Rothenberg, K. E., S. S. Neibart, A. S. LaCroix, and B. D. Hoffman. “Controlling Cell Geometry Affects the Spatial Distribution of Load Across Vinculin.” Cellular and Molecular Bioengineering 8, no. 3 (September 21, 2015): 364–82. https://doi.org/10.1007/s12195-015-0404-9.

LaCroix, Andrew S., Katheryn E. Rothenberg, Matthew E. Berginski, Aarti N. Urs, and Brenton D. Hoffman. “Construction, imaging, and analysis of FRET-based tension sensors in living cells.” Methods in Cell Biology 125 (January 2015): 161–86. https://doi.org/10.1016/bs.mcb.2014.10.033.

LaCroix, Andrew S., Katheryn E. Rothenberg, and Brenton D. Hoffman. “Molecular-Scale Tools for Studying Mechanotransduction.” Annual Review of Biomedical Engineering 17 (January 2015): 287–316. https://doi.org/10.1146/annurev-bioeng-071114-040531.

Yan, Chao, Degang Liu, Liwei Li, Michael F. Wempe, Sunny Guin, May Khanna, Jeremy Meier, et al. “Discovery and characterization of small molecules that target the GTPase Ral.” Nature 515, no. 7527 (November 2014): 443–47. https://doi.org/10.1038/nature13713.

Leerberg, Joanne M., Guillermo A. Gomez, Suzie Verma, Elliott J. Moussa, Selwin K. Wu, Rashmi Priya, Brenton D. Hoffman, Carsten Grashoff, Martin A. Schwartz, and Alpha S. Yap. “Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens.” Current Biology : CB 24, no. 15 (August 2014): 1689–99. https://doi.org/10.1016/j.cub.2014.06.028.

Moissoglu, Konstadinos, Volker Kiessling, Chen Wan, Brenton D. Hoffman, Andres Norambuena, Lukas K. Tamm, and Martin Alexander Schwartz. “Regulation of Rac1 translocation and activation by membrane domains and their boundaries.” Journal of Cell Science 127, no. Pt 11 (June 2014): 2565–76. https://doi.org/10.1242/jcs.149088.

Hwang, Priscilla Y., Jun Chen, Liufang Jing, Brenton D. Hoffman, and Lori A. Setton. “The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review.” Journal of Biomechanical Engineering 136, no. 2 (February 2014): 021010. https://doi.org/10.1115/1.4026360.

Hoffman, Brenton D. “The detection and role of molecular tension in focal adhesion dynamics.” Progress in Molecular Biology and Translational Science 126 (January 2014): 3–24. https://doi.org/10.1016/b978-0-12-394624-9.00001-4.

Ellis, Kathryn, Brenton D. Hoffman, and Michel Bagnat. “The vacuole within: how cellular organization dictates notochord function.” Bioarchitecture 3, no. 3 (2013): 64–68. https://doi.org/10.4161/bioa.25503.

Goguen, B. N., B. D. Hoffman, J. R. Sellers, M. A. Schwartz, and B. Imperiali. “Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes.” Angewandte Chemie-International Edition 50, no. 25 (2011): 5666–69.

Hoffman, B. D., C. Grashoff, and M. A. Schwartz. “Dynamic molecular processes mediate cellular mechanotransduction.” Nature 475, no. 7356 (2011): 316–23. https://doi.org/10.1038/nature10316.

Eucker, S. A., B. D. Hoffman, R. Natesh, J. Ralston, W. M. Armstead, and S. S. Margulies. “Development of a fluorescent microsphere technique for rapid histological determination of cerebral blood flow.” Brain Research 1326 (2010): 128–34.

Grashoff, C., B. D. Hoffman, M. D. Brenner, R. Zhou, M. Parsons, M. T. Yang, M. A. McLean, et al. “Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.” Nature 466, no. 7303 (2010): 263–66. https://doi.org/10.1038/nature09198.

Hoffman, Brenton D., and John C. Crocker. “Cell mechanics: dissecting the physical responses of cells to force.” Annual Review of Biomedical Engineering 11 (January 2009): 259–88. https://doi.org/10.1146/annurev.bioeng.10.061807.160511.

Hoffman, Brenton D., Gladys Massiera, and John C. Crocker. “Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding.” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 76, no. 5 Pt 1 (November 2007): 051906. https://doi.org/10.1103/physreve.76.051906.

Crocker, John C., and Brenton D. Hoffman. “Multiple-particle tracking and two-point microrheology in cells.” Methods in Cell Biology 83 (January 2007): 141–78. https://doi.org/10.1016/s0091-679x(07)83007-x.

Van Citters, Kathleen M., Brenton D. Hoffman, Gladys Massiera, and John C. Crocker. “The role of F-actin and myosin in epithelial cell rheology.” Biophysical Journal 91, no. 10 (November 2006): 3946–56. https://doi.org/10.1529/biophysj.106.091264.

Byfield, F. J., B. D. Hoffman, V. G. Romanenko, Y. Fang, J. C. Crocker, and I. Levitan. “Evidence for the role of cell stiffness in modulation of volume-regulated anion channels.” Acta Physiologica (Oxford, England) 187, no. 1–2 (May 2006): 285–94. https://doi.org/10.1111/j.1748-1716.2006.01555.x.